Job Information
The Trustees of Columbia University in the City of New York Postdoctoral Research Scientist in New York, New York
The Owusu-Ansah laboratory at the Department of Physiology and Cellular Biophysics in the CUIMC is seeking a highly motivated postdoctoral scientist to study the regulation of mitochondrial complex I (CI) assembly (see Murari et al., 2022, Science Advances and Murari et al., 2023, Cell Reports). The laboratory employs a combination of blue native polyacrylamide gel electrophoresis (BN-PAGE), in-gel oxidative phosphorylation (OXPHOS) activity assays, Western blots, proteomics, RNA-seq and a range of physiology and cell biology assays to dissect the function of CI. To address this question, our studies have been directed at devising a model system in which we can rigorously examine how CI is assembled, examine the roles of its multiple subunits in bioenergetics and physiology, perform genetic screens to identify new regulators of CI assembly, and create and study various rare CI disease models. While these studies are pursued in fruit flies (Drosophila melanogaster), we anticipate confirming our findings in mammalian systems.
Overview of job responsibilities:
- Design, plan and execute well-thought-out experiments to advance projects.
- Help with the supervision of technicians and summer undergraduate students to develop mentoring skills.
- Keep up-to-date with literature related to mitochondrial biology and stress responses.
- Contribute to the preparation of manuscripts for publication.
Minimum degree requirement is a PhD or equivalent in cell biology, genetics, biochemistry or other life sciences.
A candidate must have the following:
- A track record of excellent publications.
- Prior experience in assessing mitochondrial health by BN-PAGE, OXPHOS activity assays, oxygen consumption assays, confocal microscopy, proteomics or transcriptomics is strongly desired.
- Self-driven with the ability to function independently but also as part of a team.
- Strong interpersonal skills.
Columbia University is an Equal Opportunity Employer / Disability / Veteran
Pay Transparency Disclosure
The salary of the finalist selected for this role will be set based on a variety of factors, including but not limited to departmental budgets, qualifications, experience, education, licenses, specialty, and training. The above hiring range represents the University's good faith and reasonable estimate of the range of possible compensation at the time of posting.
Equal Opportunity Employer / Disability / Veteran
Columbia University is committed to the hiring of qualified local residents.
Minimum Salary: 31200.00 Maximum Salary: 31200.00 Salary Unit: Yearly