Pfizer Principal Scientist in Pearl River, New York
Why Patients Need You Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.
What You Will Achieve As a Principal Scientist, you will be at the center of our operations and you'll find that everything we do, every day, is in line with an unwavering commitment to quality. You will help execute a collaborative program to research and develop RNA-based vaccines for influenza and other viruses. The program will integrate cutting edge synthetic biology and RNA technology to rapidly and reliably respond to virus strain changes for seasonal vaccine updates and for pandemic outbreaks. The primary focus of this position will be to lead, design, implement, and innovate synthetic technology and molecular biology approaches that can rapidly, accurately, and efficiently produce high-quality DNA constructs to make game-changing RNA vaccines with superior efficacy or for other virology applications.
You will be recognized as a technical expert and a significant scientific contributor. With your deep knowledge of the discipline, you will regularly contribute at the therapeutic area level and can represent the department on multidisciplinary teams. You will be using your scientific judgment to adapt standard methods and techniques by applying prior work experience. You will undertake mentoring activities to guide team members.
It is your hard work and commitment that will make Pfizer ready to achieve new milestones and help patients across the globe.
How You Will Achieve It
Design, optimize, assemble, and produce DNA and RNA constructs to support the selection of optimal antigen and vector designs for RNA-based vaccines and other virology applications.
Establish innovative oligonucleotide and gene synthesis methods for more automated and rapid DNA generation (eg. BioXP). Remain current in the scientific literature and state-of-the-art techniques.
Design and conduct relevant molecular and cellular assays to characterize DNA/RNA constructs.
Document, interpret, and communicate experiments in this core area of expertise with a goal of advancing viral vaccine development, demonstrating high standards of scientific rigor, including compliant documentation and adherence to formal quality standards as necessary.
Mentor junior scientists' activities and provide technical guidance when necessary, managing one or more junior scientists
Collaborate with those from within the group, from other subdivisions of viral vaccines, from other divisions of Pfizer, and potentially from external partners.
PhD in molecular biology, molecular virology, or a related field with 6+ years of relevant post-doc experience.
Advanced knowledge of viral vector designs, expression vectors, gene synthesis, and DNA assembly methods .
Highly skilled in molecular and synthetic biology, including bioinformatic sequence design, oligonucleotide and gene synthesis, DNA assembly and amplification (Gibson assembly, Golden Gate cloning, RCA, etc.), protein expression, molecular cloning, enzymatic manipulations of nucleic acids, sequencing analysis, and PCR/qPCR.
Strong written and oral communication skills
Ability to work well in sight of aggressive timelines and excellence in multitasking
Ability to work and solve problems in interdisciplinary teams
Highly organized, detail-oriented individual
Demonstrates curiosity and creative desire to answer scientific questions
Be adaptable to take on the group's scientific challenges as they arise.
Industry experience in pre-clinical vaccine research and development
Experience with alphavirus replication and use as vectors
Experience with RNA structure/biology and molecular virology
Experience with tissue culture and cell-based assays
Experience managing/supervising/training junior staff
Other Job Details:
Eligible for employee referral programs: YES
Eligible for relocation support: YES
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